Cortactin in Epithelial–Mesenchymal Transition
نویسندگان
چکیده
منابع مشابه
Association of NEDD9 with TGF-β-triggered epithelialmesenchymal transition and cell invasion in prostate cancer cells: implications for cancer aggressiveness
NEDD9 belongs to the Cas (Crk-associated substrate) family, proteins of which mediate downstream signaling processes including cell-cycle, tumorigenesis and cytoskeletal organization. In epithelial-mesenchymal transition (EMT), NEDD9 plays an important role, but the functional mechanism underlying NEDD9-mediated EMT in prostate cancer (PCa) remains uncertain. Recently we confirmed that NEDD9 is...
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An extensive body of work has demonstrated that atherosclerotic plaques form preferentially at sites of disturbed blood flow encountered at vessel bifurcations, resulting in part from the loss of anti-inflammatory, antithrombotic, and antioxidative effects that occur in straight vessel segments because of laminar pulsatile flow. The production of nitric oxide (NO) by endothelial NO synthase (eN...
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BACKGROUND Epithelial to mesenchymal transition (EMT) contributes to metastases in various types of tumors, and is also the key step in the breast cancer metastatic cascade. In our previous study, a mouse model containing human-derived normal breast tissue was established and allowed EMT/MET process of human breast cancer cells to be mimicked in a humanized mammary microenvironment. MATERIAL AN...
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stress fibers, do not contain cortactin. Despite the substantial size of the cortactin literature (currently the word “cortactin” appears in 339 articles), the most fundamental questions are still open. Thus, although cortactin has been implicated in the above-mentioned processes, its exact role is still not clearly defined. Its obvious participation in many of these fundamental events together...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2020
ISSN: 2296-634X
DOI: 10.3389/fcell.2020.585619